strontium citrate pros and cons

Research from Europe suggests that patients on strontium ranelate may have an increased risk of heart attacks. Strontium Boost is an all-natural organic supplement that supports bone health in people of every age. Gedalia, I., Brayer, L., Kalter, N., Richter, M., and Stabholz, A. Rev Rhum Engl Ed 1997;64(12):825-834. Membership to ConsumerLab.com is available online and provides immediate access to reviews of more than 1,000 products from over 400 brands. O'Donnell, S., Cranney, A., Wells, G. A., Adachi, J. D., and Reginster, J. Y. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Reginster, J., Minne, H. W., Sorensen, O. H., Hooper, M., Roux, C., Brandi, M. L., Lund, B., Ethgen, D., Pack, S., Roumagnac, I., and Eastell, R. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. A 2007 study only involved six participants, but the researchers found thatregular toothbrushing with a strontium-supplemented toothpaste has been found to increase the strontium content in the exposed enamel, which can be an advantage in the prevention of cariogenesis. (15) What is cariogenesis? 5-3-2007;356(18):1809-1822. In Australia and some countries in Europe, a form of strontium called strontium ranelate (Osseor Protelos) is available as a prescription medication to treat and prevent osteoporosis and bone fractures. The drug name for this radioactive form is Metastron. 1992;19(10):737-740. Accordingto the United States Department of Agriculture, Americans consume around 0.7 pounds celestite, which is used in strontium metal alloys. Peng H, Yao F, Xiong S, Wu Z, Niu G, Lu T. Strontium in public drinking water and associated public health risks in Chinese cities. 2009;20(10):1663-1673. J.Clin.Endocrinol.Metab 2005;90(5):2816-2822. Incidence and mortality of venous thrombosis: a population-based study. I was diagnosed with osteopenia", "I have osteoporosis and am afraid of the treatments for it have been trying strontium citrate", "My wife has severe Osteoporosis .It has been improving with Medicines, Yearly injections , Exercise ,". 5 Reasons to Add Lamb Meat to Your Diet. Hello @bonelady. A prescription form of strontiumstrontium ranelate (the ranelate salt), known as Protelos/Osseor was authorized in the European Union to treat severe osteoporosis in women who have been through the menopause and men who are at high risk of broken bones or fracture in the spine and the hip. If you have questions on the differences between esomeprazole (Nexium) and esomeprazole strontium, or whether esomeprazole (Nexium) is an option for you, talk to your provider or pharmacist. Protos [Product Information]. Research shows that a special prescription form of strontium (strontium-89 chloride) given intravenously (by IV) reduces pain from metastatic, Weak and brittle bones (osteoporosis). Positive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures. El-Hajj Fuleihan G. Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same? Clin Chem 2000;46:248-51. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. 2008;19(4):503-510. If you check your calcium supplement and the supplement facts include calcium carbonate, calcium citrate, or some other name, it is simply ground rocks. All rights reserved. Rozhinskaia, L. I., Arapova, S. D., Dzeranova, L. K., Molitvoslovova, N. N., Marova, E. I., Il'in, A. V., Benevolenskaia, L. I., Nikitinskaia, O. Osteoporos.Int. Expert.Opin.Pharmacother. Rousselet F, El Solh N, Maurat JP, et al. Kidney Int 2003;64:534-43. . Toxicological profile for strontium. View abstract. Uchida, A., Wakano, Y., Fukuyama, O., Miki, T., Iwayama, Y., and Okada, H. Controlled clinical evaluation of a 10% strontium chloride dentifrice in treatment of dentin hypersensitivity following periodontal surgery. I am fortunate to have no noticeable side effects. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. Ardissino G, Schmitt CP, Bianchi ML, et al. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., Wang, O., and Mitlak, B. H. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. I just read this article about strontium. View abstract. Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. BMC.Musculoskelet.Disord. A., Johansson, H., Oden, A., and McCloskey, E. V. A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX((R)). Strontium ranelate is available as a prescription medication in Europe and Australia, but it has not been approved by the FDA in the United Sates. A generic, non-branded version of strontium ranelate, from Aristo Pharma Ltd., is still available in the U.K.[2] with a number of special warnings and precautions for its use. Baziotis N, Yakoumakis E, Zissimopoulos A, et al. I now take 680 mg strontium citrate without side effects and the fractures have stopped. 2006;3:CD005326. 1987;66(10):1518-1522. Eur.J.Endocrinol. Radiat.Environ.Biophys. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. View abstract. 1996;67(8):737-742. Its been interesting what research has shown to date aboutits use for osteoporosis. What Is Secondary Prevention of Osteoporosis? To avoid this interaction, take strontium at least 2 hours before or after taking quinolones. Rizzoli R, Chapurlat RD, Laroche JM, et al. (5a). J Biol Chem 1972;247:5520-6. 2007;18(12):1617-1624. The American Bone Health Fracture Risk Calculator estimates fracture risk for women and men over age 45. Hello @bonelady welcome to Connect. Some years later in 1808, it was was isolated in its metallic formusing electrolysisby Sir Humphry Davy at the Royal Institution in London. Oger, E. Incidence of venous thromboembolism: a community-based study in Western France. Reduce bone loss and build stronger muscles. Strontium ranelate is associated with other harmful effects, including serious skin reactions, disturbances in thinking, seizures, liver inflammation, and reduced numbers of red blood cells. How Well are You Living With Ankylosing Spondylitis? 2011;22(8):2347-2355. If you want to take a strontium supplement, ask your doctor first. Reginster, J. Y., Deroisy, R., Dougados, M., Jupsin, I., Colette, J., and Roux, C. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS trial. Its been compared to calcium in its bone-boosting abilities. View abstract. Delayed strontium absorption in post-menopausal osteoporosis and osteomalacia. J.Am.Dent.Assoc. 2014 Apr;61:48-54. doi: 10.1016/j.bone.2014.01.002. Several types of calcium supplements are available are on the market in the U.S. [1] PRAC recommends suspending use of Protelos/Osseor. 2014.https://www.ema.europa.eu/en/news/prac-recommends-suspending-use-protelososseor, [2] Royal Osteoporosis Society. Towheed TE, Maxwell L, Anastassiades TP, et al. Clin Sci 1968;34:351-63. Strontium controls the activity of OPG and RANKL; these are essential molecules that regulate the rates of bone resorption. https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869. Low . Reginster, J. Y. Strontium-89 chloride in the treatment of bone metastases from breast cancer. They can decrease strontium absorption. Stable strontiums atomic symbol is Sr, its atomic number is 38 and its atomic weight is 87.62. Most calcium supplements are big and difficult to swallow. With a few simple measures, the application of Sr-89 causes no problems. After a 7-day . @faith123, recently posted about having a second reclast infusion recently here, https://connect.mayoclinic.org/discussion/reclast-infusion/. View abstract. Glucosamine therapy for treating osteoarthritis. View abstract. It seems to play a role in how your body makes new bone while it slows the breakdown of old bone. 2005 - 2023 WebMD LLC. I'm glad you found us. It does not recommend it as a treatment for anyonewho has or has had heart or circulatory problems such as stroke, heart attack, or obstruction of the blood flow in the arteries. View abstract. Pearce, E. I. and Sissons, C. H. The concomitant deposition of strontium and fluoride in dental plaque. Schrooten I, Elseviers MM, Lamberts LV, et al. A. According to Cancer Research UK, If there are cancer cells in more than one area of bone, radioactive strontium can work well to treat those areas and reduce pain. (11). View abstract. (2). https://americanbonehealth.org/bonesense/why-strontium-is-not-good-for-bone-health/ A number of studies have shown that it can strengthen bone and reduce the risk of fractures, even among women 74 years of age or older when risks are highest. [3] Bartl, R. & Bartl, C.The Osteoporosis Manual: Prevention. am in the same situation, I wish someone from mayo could give a good answer to us. JAMA 12-17-2003;290(23):3115-3121. It is not approved in the USA.[3]. View abstract. View abstract. It is also among the forms of Strontium supplements backed by studies regarding safety and efficiency. Best Joint Supplements In 2023: Knee Pain & Joint Support. B., Gamble, G. D., and Reid, I. R. Effect of osteoporosis treatment on mortality: a meta-analysis. 1991;13(3):21-25. Performance Lab Flex - Best For Athletes. Gunawardana DH, Lichtenstein M, Better N, Rosenthal M. Results of strontium-89 therapy in patients with prostate cancer resistant to chemotherapy. Some research shows that taking strontium ranelate helps prevent. Recker R, Stakkestad J Weber T et al. Vlad, S. C., LaValley, M. P., McAlindon, T. E., and Felson, D. T. Glucosamine for pain in osteoarthritis: why do trial results differ? View abstract. Use strontium supplements with caution if you have kidney disease. The naturally occurring form is made up of four stable isotopes: Sr-88 (82.6 percent), Sr-86 (9.9 percent), Sr-87 (7.0 percent), and Sr-84 (0.56 percent). This is more important for postmenopausal women. The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest. View abstract. View abstract. Oncology 1998;55:377-81. Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. (Accessed 01 August 2006). @faith123, recently posted about having a second reclast infusion recently here, https://connect.mayoclinic.org/discussion/reclast-infusion/. Lets talk about these answers and more. Cochrane.Database.Syst.Rev. Dermatology 2000;200(3):244-246. The possible risks of strontium warrant more long-term independent studies. 2008;83(5):308-314. Cochrane.Database.Syst.Rev. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This decreases the amount of tetracyclines that can be absorbed. Strontium is a natural element. View abstract. Rachitogenic activity of dietary strontium. J Natl Med Assoc 2002;94:706-11. View abstract. 2010;30(7):863-869. Strontium may also influence other essential functions, including calcium absorption, bone formation & breakdown, and it restores alkaline pH to improve the health of skin, hair, and nails). View abstract. View abstract. Quintessence.Int. Perit Dial Int 1998;18:410-4. Bone 2006;38(2 Suppl 1):23-27. Please note the date of the last review on all articles. April 2004. 2010;21(2):49-55. View abstract. Kidney Int. Sr should be used with caution for those with kidney disease and if you have advanced kidney disease, then strontium ranelate is not recommended at all. Instant breakfast drink, various flavors and brands, powder prepared with water, 8 ounces 105-250 mg per serving. It can be found in soil and seawater as well as some foods. J.Bone Miner.Res. A double-blind, randomized placebo-controlled trial published in The Journal of Clinical Endocrinology and Metabolism looked at the effects of Sr on 261 men with primary osteoporosis. Drug Ther Bull. Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. Its a fancy word for the development of cavities! Omdahl JL, DeLuca HF. What else is it good for? Johnson, G. H., Bales, D. J., Gordon, G. E., and Powell, L. V. Clinical performance of posterior composite resin restorations. 2012;23(1):295-303. doi: 10.1007/s00198-011-1547-8. Bruyre O, Reginster JY, Bellamy N, et al. 2011;(7):CD003347. J.Bone Joint Surg.Am. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. Type: Natural Calcium & Magnesium Supplement. This could cause the body to have too much strontium and potentially cause side effects. In the mean time I do have bone density scans to keep an eye on bone density. View abstract. (3). Doctors can prescribe it only for postmenopausal women and for men with severe osteoporosis who cant take other drugs. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Diagnosis and Management. Obtaining strontium from your diet by eating seafood, whole grains,beans, spinach, lettuce, celery, androot vegetableslike carrots and potatoes is the safest way to boost your strontium levels. Rizzoli, R., Laroche, M., Krieg, M. A., Frieling, I., Thomas, T., Delmas, P., and Felsenberg, D. Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis. Spets-Happonen, S., Seppa, L., Korhonen, A., and Alakuijala, P. Accumulation of strontium and fluoride in approximal dental plaque and changes in plaque microflora after rinsing with chlorhexidine-fluoride-strontium solution. The most common form of strontium in nutritional supplements is strontium citrate. View abstract. Boron is an element. View abstract. Hunter House, 2014. Any feedback to help me through this maze will be highly appreciated. View abstract. You also do not know whether they can seriously harm you. J Periodontol. The effect of a strontiumhloridetoothpaste on root hypersensitivity in a controlled clinical study. Quilty PM, Kirk D, Bolger JJ, et al. Can and should treatments such as these be used in conjunction with strontium citrate, about which I know nothing by the way? Taking strontium with tetracyclines can decrease their effects. Natural strontium has a silvery white metallic color with a tint of yellow. View abstract. N.Engl.J.Med. Sr-89 has been used as a form of treatment to manage pain resulting from bone pain due to cancer. 2010;30(10):1341-1348. Manicourt, D. H., Azria, M., Mindeholm, L., Thonar, E. J., and Devogelaer, J. P. Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis. Robinson, R. G., Spicer, J. (23), In general, taking very high doses of a Sr supplement is typically not considered safe and taking too much could even damage bones, so be careful when taking strontium, as recommended by the ATSDR (Agency for Toxic Substances and Disease Registry). View abstract. Ann Rheum Dis. View abstract. Strontium 89 in the treatment of pain due to diffuse osseous metastases: a university hospital experience. Oral Dis. Results 12 weeks following cessation of 8 weeks' supervised use. 2010;21(4):667-677. Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients. Contact Dermatitis 2000;42(2):98-100. Bruyere, O., Delferriere, D., Roux, C., Wark, J. D., Spector, T., Devogelaer, J. P., Brixen, K., Adami, S., Fechtenbaum, J., Kolta, S., and Reginster, J. Y. Wang, C. T., Lin, J., Chang, C. J., Lin, Y. T., and Hou, S. M. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. Cochrane Database Syst Rev 2006;(4):CD005326. 1980;51(10):578-581. Zinc is crucial for various functions in the body, including: 1. How can Sr be used? A special form of strontium called strontium ranelate can increase bone formation and prevent bone loss when used in postmenopausal women with osteoporosis. All Rights Reserved. Its also used to create that alerting red color in emergency flares. Chesnut III, C. H., Skag, A., Christiansen, C., Recker, R., Stakkestad, J. 11 possible benefits. Calcium citrate has an acidic base, so it doesn't require hydrochloric acid for absorption. A. Arch Dis Child 1996;75:524-6. Strontium as a marker for intestinal calcium absorption: the stimulatory effect of calcitriol. 2008;58(6):1687-1695. 1998-2023 Mayo Foundation for Medical Education and Research. View abstract. View abstract. Les Laboratoires Servier ceased the distribution of Protelos/Osseor in August 2017. 1970;41(12):702-703. This supplement supports healthy osteoblast differentiation osteoblast collagen formation and balanced osteoclast activity; all of these activities help you maintain bone tensile strength. Thromb.Haemost. View abstract. Blitzer, B. There were, however, significant increases in both heart attacks and blood clots (including pulmonary embolism) in patients taking strontium ranelate compared to those who were not. View abstract. Osteoporosis Int. So what is stable strontium exactly? European Medicines Agency, 2005. Do not take it within 2 hours of ingesting calcium so I take it at bedtime. View abstract. View abstract. If youre suffering from bone or prostate cancer, radioactive strontium therapyshould only be given by or under the direct supervision of a doctor with specialized training in nuclear medicine or radiation oncology. A coordinator will follow up to see if Mayo Clinic is right for you. View abstract. Skoryna SC. Clin Nucl Med 2004;29:81-5. View abstract. 2003;14 Suppl 3:S56-S65. J.Clin.Dent. View abstract. Arrich, J., Piribauer, F., Mad, P., Schmid, D., Klaushofer, K., and Mullner, M. Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis. Strontium ranelate discontinued. You are lucky to still be able to get some control over this. Effects of oral supplementation with stable strontium. 2-1-2001;344(5):333-340. Dr. Lanis No-Nonsense Bone Health Guide. View abstract. Kanapka, J. A., Thompson, D. E., Nevitt, M. C., Bauer, D. C., Genant, H. K., Haskell, W. L., Marcus, R., Ott, S. M., Torner, J. C., Quandt, S. A., Reiss, T. F., and Ensrud, K. E. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. View abstract. View abstract. Rheumatol.Int. (14). Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. In addition to possibly helping to reduce painful tooth sensitivity, strontium may be helpful when it comes to tooth decay and cavities. and I don't hear much about it. J Periodontol 1987;58:470-4. 2006;21(7):1113-1120. N.Engl.J.Med. Cochrane Database Syst Rev 2005;(2):CD002946. Although diet is the best way to get calcium, calcium supplements may be an option if your diet falls short. The radioactive form of Sr is not available as a dietary supplement, but it is considered to likely be safe when administered by a health care professional by IV. There are many safe food sources and if you are not able to reach your daily calcium requirements through your diet, you may need a supplement. Description Pure Encapsulations' Strontium capsules provide one of the many trace minerals essential to bone health. Busse, B., Jobke, B., Hahn, M., Priemel, M., Niecke, M., Seitz, S., Zustin, J., Semler, J., and Amling, M. Effects of strontium ranelate administration on bisphosphonate-altered hydroxyapatite: Matrix incorporation of strontium is accompanied by changes in mineralization and microstructure. 1990;34(3):545-560. Silverstein, M. D., Heit, J. Reginster, J. Y., Felsenberg, D., Boonen, S., Diez-Perez, A., Rizzoli, R., Brandi, M. L., Spector, T. D., Brixen, K., Goemaere, S., Cormier, C., Balogh, A., Delmas, P. D., and Meunier, P. J. 2007;5(4):692-699. My bone density has shown some improvement and no further decline. Br.J.Clin.Pharmacol. Cheung, K. M., Lu, W. W., Luk, K. D., Wong, C. T., Chan, D., Shen, J. X., Qiu, G. X., Zheng, Z. M., Li, C. H., Liu, S. L., Chan, W. K., and Leong, J. C. Vertebroplasty by use of a strontium-containing bioactive bone cement. View abstract. People with prostate cancer sometimes have the cancer metastasize and spread to their bones. A., Hoiseth, A., Felsenberg, D., Huss, H., Gilbride, J., Schimmer, R. C., and Delmas, P. D. Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J.Clin.Periodontol. View abstract. 2005;7(3):R625-R633. A., Cosman, F., Lakatos, P., Leung, P. C., Man, Z., Mautalen, C., Mesenbrink, P., Hu, H., Caminis, J., Tong, K., Rosario-Jansen, T., Krasnow, J., Hue, T. F., Sellmeyer, D., Eriksen, E. F., and Cummings, S. R. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. Some male hormones include testosterone, nandrolone, oxandrolone, and oxymetholone. Black, D. M., Cummings, S. R., Karpf, D. B., Cauley, J. J Am Diet Assoc 1987;87:1644-50. Eisenberg E. Effects of androgens, estrogens and corticoids on strontium kinetics in man. The body needs zinc for the immune system to work properly. Marquis, P., Roux, C., de la Loge, C., Diaz-Curiel, M., Cormier, C., Isaia, G., Badurski, J., Wark, J., and Meunier, P. J. Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis. Good luck to all of you. 1992;23(10):705-711. View abstract. J BoneMiner Res 2002;17 [Suppl 1](S35). Most people who take strontium citrate report their fractures STOP. Strontium is a mineral found in seawater and soil. 2008;67(12):1736-1738. Middleton ET, Steel SA, Aye M, Doherty SM. Zinner, D. D., Duany, L. F., and Lutz, H. J. 2006;54(11):3494-3507. In your diet, you get it mainly from seafood, but you can also get small amounts of it in whole milk, wheat bran, meat, poultry, and root vegetables. While it may seem intimidating at first, counting macros is a common Erythritol is now one of the most popular natural zero-calorie sweeteners available. View abstract. Two years ago I was put on vacation from the reclast and havent received any further infusions. The PRAC weighed the benefits of the medicine against the known risks and concluded that the balance was no longer favourable and recommended Protelos/Osseor be suspended until there are new data showing a favourable balance in a defined patient group.[1]. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. J.Bone Miner.Res. Many consumers are being lured by the advertised benefits of strontium for bone health. They won't do any studies but the END OF FRACTURES SAYS IT ALL! WebMD does not provide medical advice, diagnosis or treatment. 2000;11(1):83-91. It is also shown to positively impact the body's usage of testosterone, estrogen, and vitamin D. 2004;5(7):1635-1638. Robinson RG, Preston DF, Schiefelbein M, Baxter KG. These forms are different from the ranelate compound and there have been no studies showing that they are safe or effective. J Clin Endocrinol Metab 1966;26:566-72. It's derived from rock calcium bound with citric acid (think citrus juices, especially lime and lemon). Quintessence.Int. Both soil and seawater contain this mineral. I was told by the endocrinologist who I went to for osteoporosis that AlgaeCal is no better than taking calcium and vitamin D. I am reading the book "Strong Women, Strong Bones" and I highly recommend it. View abstract. Phone & Address: 1-800-820-0184; support@algaecal.com.

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